Smart biomaterial-based systems for intrinsic stimuli-responsive chronic wound management

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Alves, PM (Author) Other; Barrias, CC (Author) Other; Paula Gomes (Author) FCUP; Martins, MCL (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: MATERIALS TODAY CHEMISTRY

Vol. 22

ISSN: 2468-5194

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00V-N7B

DOI: 10.1016/j.mtchem.2021.100623

Abstract (EN): Skin chronic wounds are associated with a state of persistent inflammation and often with infection, originating a specific microenvironment characterized by increased temperature, alkaline pH, elevated enzymatic activity, and high levels of reactive oxygen species (ROS). These alterations can be explored as intrinsic triggers in the design of stimuli-responsive biomaterials for the release of bioactive molecules at the wound microenvironment. Stimuli-responsive biomaterials may not only prolong the bioactivity of the therapeutic agents but also synchronize it with the healing stages, tuning the wound treatment. In addition, the high activity of enzymes, such as lysozyme in infected chronic wounds, as well as the shift to a more alkaline pH may be used as biomarkers for early detection of infected and/or non-healing wounds. Overall, although a few shortcomings still need to be addressed before clinical translation, the bioengineered smart formulations highlighted in this review stand out as a new generation of therapies to manage skin chronic wounds.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13