Using radiobiology simulators for evaluation of 99mTc Auger electrons for targeted tumor radiotherapy

• Type: Chapter or Part of a Book
• Date: 2011

Authors

Tavares, AAS (Author) Other; João Manuel R. S. Tavares (Author) FEUP

Book

Title: Technology and Medical Sciences - TMSi 2010

Pages: 311-312

ISBN: 9780203816592; 9781138112896

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-00J-0PE

DOI: 10.1201/b11330-61

Abstract (EN): Technetium-99m (99mTc) has been widely used as an imaging agent; however, few studies evaluated its potential use as therapeutic agent. The present study aimed to analyze the potential use of 99mTc Auger electrons for targeted tumor radiotherapy by computational methods. Thus, three different computational simulators were used to estimate the yield of DNA damage, the probability of correct repair and cell kinetic effects after irradiation with 99mTc electrons, iodine-131 beta minus particles and astatine-211 alpha particles. Based on the obtained results, it is possible to conclude that 99mTc CKMMX (all M-shell Coster-Kroning-CK-and super CK transitions) electrons and Auger MXY (all M-shell Auger transitions) are valuable for targeted tumor radiotherapy.

Language: English

Type (Professor's evaluation): Scientific