Gold nanostructures as mediators of hyperthermia therapies in breast cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Granja, A (Author) Other; Pinheiro, M (Author) Other; Sousa, CT (Author) FCUP; Salette Reis (Author) FFUP

Journal

Title: Biochemical Pharmacology

Vol. 190

ISSN: 0006-2952

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

Other information

Authenticus ID: P-00V-75T

DOI: 10.1016/j.bcp.2021.114639

Abstract (EN): Breast cancer is the leading cause of cancer-related deaths among women. Due to the limitations of the current therapeutics, new treatment options are needed. Hyperthermia is a promising approach to improve breast cancer therapy, particularly when combined with chemo and radiotherapy. This area has gained more attention following association with nanotechnology, with the emergence of modalities, such as photothermal therapy (PTT). PTT is a simple, minimally invasive technique that requires a near infrared (NIR) light source and a PTT agent. Gold nanostructures are excellent PTT agents as they offer biocompatibility, versatility, high photothermal conversion efficiency, imaging contrast and an easily-modified surface. In this review, we describe the molecular basis and the current clinical aspects of hyperthermia-based therapies. The emergent area of nanoparticleinduced hyperthermia will be explored, in particular gold nanostructure-mediated PTT, focusing on recent preclinical studies for breast cancer management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19