Aspergillus and other respiratory fungal infections in the ICU: diagnosis and management

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Paiva, J-A (Author) FMUP; Mergulhao, P (Author) FMUP; Pereira, JM (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CURRENT OPINION IN INFECTIOUS DISEASES

Vol. 31

Pages: 187-193

ISSN: 0951-7375

Publisher: Lippincott Williams & Wilkins

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-00N-SA3

DOI: 10.1097/qco.0000000000000436

Abstract (EN): Purpose of review Filamentous fungi respiratory infections, namely because of Aspergillus, Mucorales, Fusarium, or Scedosporium, show rising incidence and occur more in populations which are not classically immunosuppressed. This and their persistent dismal prognosis are the focus of this review. Recent findings Both an early diagnosis, rooted on a high level of suspicion and based on clinical picture, radiology, cultural microbiological exams, fungal biomarkers, PCR and biopsy, and an early therapy, including immunorecovery, whenever possible, good antifungal selection, and surgery for source control, are paramount to maximize the outcome in these diseases. An evolving antifungal armamentarium and a more Pharmacokinetics/Pharmacodynamics-based antifungal prescription may help to improve the prognosis. Summary Improved awareness of these infections may increase the level of suspicion, promoting early diagnosis and treatment, ideally supported with expert stewardship.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7