Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Bassetti, M (Author) Other; Giacobbe, DR (Author) Other; Vena, A (Author) Other; Trucchi, C (Author) Other; Ansaldi, F (Author) Other; Antonelli, M (Author) Other; Adamkova, V (Author) Other; Alicino, C (Author) Other; Almyroudi, MP (Author) Other; Atchade, E (Author) Other; Azzini, AM (Author) Other; Carannante, N (Author) Other; Carnelutti, A (Author) Other; Corcione, S (Author) Other; Cortegiani, A (Author) Other; Dimopoulos, G (Author) Other; Dubler, S (Author) Other; Garcia Garmendia, JL (Author) Other; Girardis, M (Author) Other; Cornely, OA (Author) Other; Ianniruberto, S (Author) Other; Kullberg, BJ (Author) Other; Lagrou, K (Author) Other; Le Bihan, C (Author) Other; Luzzati, R (Author) Other; Malbrain, MLNG (Author) Other; Merelli, M (Author) Other; Marques, AJ (Author) Other; Martin Loeches, I (Author) Other; Mesini, A (Author) Other; Paiva, J-A (Author) FMUP; Peghin, M (Author) Other; Raineri, SM (Author) Other; Rautemaa Richardson, R (Author) Other; Schouten, J (Author) Other; Brugnaro, P (Author) Other; Spapen, H (Author) Other; Tasioudis, P (Author) Other; Timsit, JF (Author) Other; Tisa, V (Author) Other; Tumbarello, M (Author) Other; van den Berg, CHSB (Author) Other; Veber, B (Author) Other; Venditti, M (Author) Other; Voiriot, G (Author) Other; Wauters, J (Author) Other; Montravers, P (Author) Other

Journal

Title: Critical Care

Vol. 23

ISSN: 1364-8535

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 55 Citations

Scopus - 55 Citations

Other information

Authenticus ID: P-00Q-Q1F

DOI: 10.1186/s13054-019-2497-3

Abstract (EN): BackgroundThe objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe.MethodsA multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU).ResultsDuring the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p<0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis.ConclusionsThe cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7