Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model
Publication

Publications

From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model

Title
From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model
Type
Article in International Scientific Journal
Year
2017
Authors
Jarak, I
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Carrola, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Barros, AS
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page Without ORCID
Gil, AM
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Pereira, MD
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Corvo, ML
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Duarte, IF
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Vol. 159
Pages: 422-435
ISSN: 1096-6080
Other information
Authenticus ID: P-00N-2V0
Abstract (EN): Although silver nanoparticles (AgNPs) are widely disseminated and show great potential in the biomedical field, there is a recognized need to better understand their action at the metabolic and functional levels. In this work, we have used NMR metabolomics, together with conventional clinical chemistry and histological examination, to characterize multi-organ and systemic metabolic responses to AgNPs intravenously administered to mice at 8 mg/kg body weight (a dose not eliciting overt toxicity). The major target organs of AgNPs accumulation, liver and spleen, showed the greatest metabolic changes, in a clear 2-stage response. In particular, the liver of dosed mice was found to switch from glycogenolysis and lipid storage, at 6 h postinjection, to glycogenesis and lipolysis, at subsequent times up to 48 h. Moreover, metabolites related to antioxidative defense, immunoregulation and detoxification seemed to play a crucial role in avoiding major hepatic damage. The spleen showed several early changes, including depletion of several amino acids, possibly reflecting impairment of hemoglobin recycling, while only a few differences remained at 48 h postinjection. In the heart, the metabolic shift towards TCA cycle intensification and increased ATP production possibly reflected a beneficial adaptation to the presence of AgNPs. On the other hand, the TCA cycle appeared to be down regulated in the lungs of injected mice, which showed signs of inflammation. Thekidneys showed the mildest metabolic response to AgNPs. Overall, this study has shown that NMR metabolomics is a powerful tool to monitor invivo metabolic responses to nanoparticles, revealing unforeseen effects.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 14
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

The Mixture of "Ecstasy" and Its Metabolites Impairs Mitochondrial Fusion/Fission Equilibrium and Trafficking in Hippocampal Neurons, at In Vivo Relevant Concentrations (2014)
Article in International Scientific Journal
Daniel J Jose Barbosa; Roman Serrat; Serena Mirra; Marti Quevedo; Elena G Gomez de Barreda; Jesus Avila; Luisa Maria Ferreira; Paula Serio Branco; Eduarda Fernandes; Maria de Lourdes Bastos; Joao Paulo Capela; Eduardo Soriano; Felix Carvalho
The Cannabinoid Delta-9-tetrahydrocannabinol Disrupts Estrogen Signaling in Human Placenta (2020)
Article in International Scientific Journal
Maia, J; Almada, M; Midao, L; Fonseca, BM; Braga, J; Goncalves, D; Teixeira, N; Georgina Correia da Silva
SLC19A1, SLC46A1 and SLCO1B1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients (2014)
Article in International Scientific Journal
Lima, A; Bernardes, M; Azevedo, R; Monteiro, J; Sousa, H; Rui Medeiros; Seabra, V
Silver nanoparticles induce an inflammatory response of intestinal C2BBe1 Cells (2023)
Article in International Scientific Journal
A. Sousa; A. T. Rufino; A. Ramalho; F. Carvalho; Eduarda Fernandes; M. Freitas

See all (11)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-23 at 19:24:41 | Privacy Policy | Personal Data Protection Policy | Whistleblowing