Lipid nanoparticles coated with chitosan using a one-step association method to target rifampicin to alveolar macrophages

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Vieira, ACC (Author) Other; Chaves, LL (Author) Other; Pinheiro, M (Author) Other; Lima, SC (Author) FFUP; Neto, PJR (Author) Other; Ferreira, DC (Author) FFUP; Sarmento, B (Author) Other; Salette Reis (Author) FFUP

Journal

Title: Carbohydrate Polymers

Vol. 252

ISSN: 0144-8617

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00S-TDJ

DOI: 10.1016/j.carbpol.2020.116978

Abstract (EN): This work proposes the development and characterization of solid lipid nanoparticles (SLNs) loaded with rifampicin (RIF) aiming to enhance mucoadhesion of the SLNs and consequently internalization by the alveolar macrophages (AMs). The lipid nanoparticles (NPs) were characterized and the results showed that the NPs obtained present a spherical or a starry shape with diameter around 250-500 nm, a monodisperse population, with zeta potential between-31 mV for uncoated SLNs and +33 mV for coated SLNs. The drug EE was approximately 90 % and the loading capacity (LC) 4.5 %. The SLNs coated with chitosan by the association method (aC-SLNs) show an effective mucoadhesive profile, verified by the turdimetry and surface loading method, corroborated with the cellular assays. The presence of chitosan in the aC-SLNs promotes higher mucoadhesive properties to the NPs and permeability in A549, suggesting that the safe aC-SLNs-RIF can be used as a promising drug delivery system for improving tuberculosis treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8