The CAG repeat within the androgen receptor gene and its relationship to cryptorchidism

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Silva Ramos, M (Author) Other; Oliveira, JM (Author) Other; Cabeda, JM (Author) Other; Reis, A (Author) Other; Soares, J (Author) Other; Pimenta, A (Author) Other

Journal

Title: International Braz J Urol

Vol. 32 No. 6

Pages: 330-334

ISSN: 1677-5538

Indexing

Scopus - 26 Citations

Other information

Authenticus ID: P-007-FWM

DOI: 10.1590/s1677-55382006000300014

Abstract (EN): Purpose: We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism. Materials and Methods: Genomic deoxyribonucleic acid (DNA) was extracted from blood samples from 42 cryptorchid boys and from 31 non-cryptorchid control subjects. In the cryptorchid group, 7 had bilateral cryptorchidism and 6 had patent processus vaginalis in the contralateral side. To determine the number of CAG repeats, the DNA was amplified by polymerase chain reaction and sequenced. Results: The mean CAG repeat length in the AR gene was 22.5 (range 16 to 28) in patients and 21.5 (range 17 to 26) in controls (non-significant). Patients with bilateral cryptorchidism had a mean length of 24.3 (range 21 to 26) and patients with unilateral cryptorchidism and patent processus vaginalis in the contra lateral side had a mean of 25.2 (range 21 to 28), which was statistically different from controls (p = 0.015 and p = 0.005 respectively). Conclusion: CAG repeat length of the AR gene does not seem to play a major role in patients with unilateral cryptorchidism. However, in patients with bilateral undescended testis, a less functional androgen receptor through a longer polyglutamine chain may have a role in its pathogenesis. In the same way, patients with unilateral cryptorchidism a contralateral patent processus vaginalis have longer CAG repeats that might be responsible for a slower testicular descent and incomplete closure of the processus vaginalis.

Language: English

Type (Professor's evaluation): Scientific