Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Bernardino, RL (Author) Other; Marinelli, RA (Author) Other; Maggio, A (Author) Other; Gena, P (Author) Other; Cataldo, I (Author) Other; Alves, MG (Author) Other; Svelto, M (Author) Other; Oliveira, PF (Author) ICBAS; Calamita, G (Author) Other

Journal

Title: International Journal Of Molecular Sciences

Vol. 17

Final page: 1096

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-00K-P4Y

DOI: 10.3390/ijms17071096

Abstract (EN): Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20