Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye ¿ Part I ¿ Barriers and determining factors in ocular delivery

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Sánchez-López, E (Author) Other; Espina, M (Author) Other; Doktorovova, S (Author) Other; Souto, E (Author) Other; García, M (Author) Other

Journal

Title: European Journal of Pharmaceutics and Biopharmaceutics

Vol. 110

Pages: 70-75

ISSN: 0939-6411

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 79 Citations

Other information

Authenticus ID: P-00Y-1F1

DOI: 10.1016/j.ejpb.2016.10.009

Abstract (EN): Ocular drug delivery is still a challenge for researchers in the field of pharmaceutical technology due to anatomical and physiological eye characteristics. The tissue barriers (such as cornea, conjunctiva, blood aqueous barrier, and blood¿retinal barrier) limit the access of drugs to their targets. Taking into account the short retention time in the precorneal area of classical ocular dosage forms (e.g. solutions, suspensions or ointments) which are rapidly eliminated by tears and eyelid movement, only less than five percent of the administered drug attains intraocular structures. With the aim to overcome ocular barriers, drug delivery systems, able to increase ocular bioavailability reducing side effects, are recognized as promising alternative. In this review, the main barriers and strategies to increase drug transport in ocular delivery are comprehensively discussed, highlighting the factors involved in ocular transport of SLN and NLC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5