Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Teixeira, MC (Author) Other; Carbone, C (Author) Other; Souto, EB (Author) Other

Journal

Title: Progress in Lipid Research

Vol. 68

Pages: 1-11

ISSN: 0163-7827

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 138 Citations

Other information

Authenticus ID: P-00N-A80

DOI: 10.1016/j.plipres.2017.07.001

Abstract (EN): Solid lipid nanoparticle (SLN), nanostructured lipid carriers (NLC) and hybrid nanoparticles, have gained increasing interest as drug delivery systems because of their potential to load and release drugs from the Biopharmaceutical classification system (BCS) of class II (low solubility and high permeability) and of class IV (low solubility and low permeability). Lipid properties (e.g. high solubilizing potential, biocompatibility, biotolerability, biodegradability and distinct route of absorption) contribute for the improvement of the bioavailability of these drugs for a set of administration routes. Their interest continues to grow, as translated by the number of patents being field worldwide. This paper discusses the recent advances on the use of SLN, NLC and lipid-polymer hybrid nanoparticles for the loading of lipophilic, poorly water-soluble and poorly permeable drugs, being developed for oral, topical, parenteral and ocular administration, also discussing the industrial applications of these systems. A review of the patents filled between 2014 and 2017, concerning the original inventions of lipid nanocarriers, is also provided.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11