D-alpha-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Teixeira, MC (Author) Other; Severino, P (Author) Other; Andreani, T (Author) Other; Boonme, P (Author) Other; Santini, A (Author) Other; Silva, AM (Author) Other; Souto, EB (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: SAUDI PHARMACEUTICAL JOURNAL

Vol. 25

Pages: 231-235

ISSN: 1319-0164

Indexing

ISI Web of Knowledge - 47 Citations

Scopus - 49 Citations

Other information

Authenticus ID: P-00M-KGB

DOI: 10.1016/j.jsps.2016.06.004

Abstract (EN): The aim of this study was the assessment of the physicochemical stability of D-alpha-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween(R)80 and Lipoid(R)S75 as surfactant and co-surfactant, respectively. D-alpha-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0.15) have been produced by high-pressure homogenization, and their surface electrical charge (zeta potential), pH, surface tension, osmolarity, and rheological behavior, were characterized as a function of the D-alpha-tocopherol loading. In vitro studies in Caco-2 cell lines confirmed the safety profile of the developed nanoemulsions with percentage of cell viability above 90% for all formulations. (C) 2016 The Authors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5