Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(epsilon-caprolactone) Nanocapsules

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Barbosa, TC (Author) Other; Nascimento, LED (Author) Other; Bani, C (Author) Other; Almeida, T (Author) Other; Nery, M (Author) Other; Santos, RS (Author) Other; Menezes, LRD (Author) Other; Zielinska, A (Author) Other; Fernandes, AR (Author) Other; Cardoso, JC (Author) Other; Jaguer, A (Author) Other; Jaguer, E (Author) Other; Sanchez Lopez, E (Author) Other; Nalone, L (Author) Other; Souto, EB (Author) Other; Severino, P (Author) Other

Journal

Title: Toxics

Vol. 7

Final page: 51

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00R-JNE

DOI: 10.3390/toxics7040051

Abstract (EN): The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(epsilon-caprolactone) carrot oil and Pluronic (R) F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen's egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(epsilon-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12