Nanoparticle Delivery Systems in the Treatment of Diabetes Complications

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Souto, EB (Author) Other; Souto, SB (Author) Other; Campos, JR (Author) Other; Severino, P (Author) Other; Pashirova, TN (Author) Other; Zakharova, LY (Author) Other; Silva, AM (Author) Other; Durazzo, A (Author) Other; Lucarini, M (Author) Other; Izzo, AA (Author) Other; Santini, A (Author) Other

Journal

Title: Molecules

Vol. 24

Final page: 4209

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 52 Citations

Scopus - 60 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00R-DB1

DOI: 10.3390/molecules24234209

Abstract (EN): Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line treatment. This administration route is however associated with limited patient's compliance, due to the risk of pain, discomfort and local infection. Nanoparticles have been proposed as insulin carriers to make possible the administration of the peptide via friendlier pathways without the need of injection, i.e., via oral or nasal routes. Nanoparticles stand for particles in the nanometer range that can be obtained from different materials (e.g., polysaccharides, synthetic polymers, lipid) and are commonly used with the aim to improve the physicochemical stability of the loaded drug and thereby its bioavailability. This review discusses the use of different types of nanoparticles (e.g., polymeric and lipid nanoparticles, liposomes, dendrimers, niosomes, micelles, nanoemulsions and also drug nanosuspensions) for improved delivery of different oral hypoglycemic agents in comparison to conventional therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 29