Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Santos, RS (Author) Other; Loureiro, KC (Author) Other; Rezende, PS (Author) Other; Andrade, LN (Author) Other; Barbosa, RD (Author) Other; Santini, A (Author) Other; Santos, AC (Author) Other; da Silva, CF (Author) Other; Souto, EB (Author) Other; de Sousa, DP (Author) Other; Amaral, RG (Author) Other; Severino, P (Author) Other

Journal

Title: Journal of Dermatological Treatment

Vol. 30

Pages: 617-626

ISSN: 0954-6634

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 4 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00Q-H3G

DOI: 10.1080/09546634.2018.1479726

Abstract (EN): Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect. The topical route is desirable due to the adverse effects arising from oral administration. This review provides a comprehensive analysis of the use of nano compounds for the current treatment of topical fungal infections. A special emphasis is given to the employment of lipid nanoparticles, due to their recognized efficacy, versatility, and biocompatibility, attracting the major attention as novel topical nanocompounds used for the administration of antifungal drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10