Therapy for prevention and treatment of skin ionizing radiation damage: a review

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Soriano, JL (Author) Other; Calpena, AC (Author) Other; Souto, EB (Author) Other; Clares, B (Author) Other

Journal

Title: International Journal of Radiation Biology

Vol. 95

Pages: 537-553

ISSN: 0955-3002

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 7 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00Q-GMV

DOI: 10.1080/09553002.2019.1562254

Abstract (EN): Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a number of independent variables such as dose, type of radiation and tissue, etc. As a result of ionizing radiation exposure, biological effects can take place in acute or long-term manner. As in the case of other self-renewing tissues (e.g. hematopoietic system and intestinal epithelium), skin is also extremely sensitive to ionizing radiation. In this way, appropriate management of radiation skin effects might improve the therapeutic benefit of medical radiation therapy, as well as reduce the mortality associated with any radiological incident (e.g. accident or terrorist attack). For this reason, current and potential future treatment approaches for skin radiation injury are reviewed in this work. Unfortunately, there is no sufficient evidence for establishing a standard treatment to prevent or mitigate radiation-induced cutaneous injury. Thus, continued research is necessary to achieve effective therapies to address this important health problem.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17