In vitro SPF and Photostability Assays of Emulsion Containing Nanoparticles with Vegetable Extracts Rich in Flavonoids

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Cefali, LC (Author) Other; Ataide, JA (Author) Other; Eberlin, S (Author) Other; Goncalves, FCD (Author) Other; Fernandes, AR (Author) Other; Marto, J (Author) Other; Ribeiro, HM (Author) Other; Foglio, MA (Author) Other; Mazzola, PG (Author) Other; Souto, EB (Author) Other

Journal

Title: AAPS PharmSciTech

Vol. 20

ISSN: 1530-9932

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-00Q-0NW

DOI: 10.1208/s12249-018-1217-7

Abstract (EN): The aim of study was to determine the in vitro sun protection factor (SPF) and the photostability profile of a topical formulation composed of nanoparticles loaded with vegetable extracts and to assess its physicochemical properties. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with flavonoids-enriched vegetable extracts (Ginkgo biloba L., Dimorphandra mollis Benth, Ruta graveolens, and Vitis vinifera L.) were produced and characterized for their morphology, mean particle size, zeta potential, and encapsulation efficiency. A final topical formulation was obtained by dispersing chitosan/TPP nanoparticles in an o/w emulsion. Results showed that nanoparticles dispersion exhibited yellowish color, spherical shape, and uniform appearance. Extract-loaded chitosan/TPP nanoparticles showed a mean particle size of 557.11 +/- 3.1nm, polydispersity index of 0.39 +/- 0.27, zeta potential of +11.54 +/- 2.1mV, and encapsulation efficiency of 75.89% of rutin. The recorded texture parameters confirm that the developed formulation is appropriate for skin application. The SPF obtained was 2.3 +/- 0.4, with a critical wavelength of 387.0nm and 0.69 UVA/UVB ratio. The developed formulation exhibited photostability, allowing the release of flavonoids from nanoparticles while retaining rutin into the skin in a higher extension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10