State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Cano, A (Author) Other; Ettcheto, M (Author) Other; Espina, M (Author) Other; Lopez Machado, A (Author) Other; Cajal, Y (Author) Other; Rabanal, F (Author) Other; Sanchez Lopez, E (Author) Other; Camins, A (Author) Other; Garcia, ML (Author) Other; Souto, EB (Author) Other

Journal

Title: Journal of Nanobiotechnology

Vol. 18

ISSN: 1477-3155

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00T-0C3

DOI: 10.1186/s12951-020-00714-2

Abstract (EN): Infectious diseases kill over 17 million people a year, among which bacterial infections stand out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual transmission diseases and nosocomial infections are the most severe bacterial infections, which affect millions of people worldwide. Moreover, the indiscriminate use of antibiotic drugs in the last decades has triggered an increasing multiple resistance towards these drugs, which represent a serious global socioeconomic and public health risk. It is estimated that 33,000 and 35,000 people die yearly in Europe and the United States, respectively, as a direct result of antimicrobial resistance. For all these reasons, there is an emerging need to find novel alternatives to overcome these issues and reduced the morbidity and mortality associated to bacterial infectious diseases. In that sense, nanotechnological approaches, especially smart polymeric nanoparticles, has wrought a revolution in this field, providing an innovative therapeutic alternative able to improve the limitations encountered in available treatments and capable to be effective by theirselves. In this review, we examine the current status of most dangerous human infections, together with an in-depth discussion of the role of nanomedicine to overcome the current disadvantages, and specifically the most recent and innovative studies involving polymeric nanoparticles against most common bacterial infections of the human body.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 24