Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Neto, CMS (Author) Other; Lima, FC (Author) Other; Morais, RP (Author) Other; de Andrade, LRM (Author) Other; de Lima, R (Author) Other; Chaud, MV (Author) Other; Pereira, MM (Author) Other; Junior, RLCD (Author) Other; Cardoso, JC (Author) Other; Zielinska, A (Author) Other; Souto, EB (Author) Other; Lima, AS (Author) Other; Severino, P (Author) Other

Journal

Title: Toxics

Vol. 9

Final page: 173

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00V-C7S

DOI: 10.3390/toxics9080173

Abstract (EN): Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose-effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10