State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks

• Type: Article in International Scientific Journal
• Date: 2021

Authors

García-Torra, V (Author) Other; Cano, A (Author) Other; Espina, M (Author) Other; Ettcheto, M (Author) Other; Camins, A (Author) Other; Barroso, E (Author) Other; Vazquez-Carrera, M (Author) Other; García, ML (Author) Other; Sánchez-López, E (Author) Other; Souto, EB (Author) Other

Journal

Title: Toxics

Vol. 10

Final page: 195

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00Y-1HK

DOI: 10.3390/toxics9080195

Abstract (EN): <jats:p>Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained.</jats:p>

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21