Non-melanoma skin cancers: physiopathology and role of lipid delivery systems in new chemotherapeutic treatments

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Souto, EB (Author) FFUP; da Ana, R (Author) Other; Vieira, V (Author) Other; Fangueiro, JF (Author) Other; Dias Ferreira, J (Author) Other; Cano, A (Author) Other; Zielinska, A (Author) Other; Silva, AM (Author) Other; Staszewski, R (Author) Other; Karczewski, J (Author) Other

Journal

Title: Neoplasia

Vol. 30

ISSN: 1522-8002

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 19 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00W-KKX

DOI: 10.1016/j.neo.2022.100810

Abstract (EN): Non-melanoma carcinoma has high incidence rates and has two most common subtypes: basal cell carcinoma and squamous cell carcinoma. This type of carcinoma is usually not fatal; however, it can destroy sensory organs such as the nose, ears, and lips. The treatment of these injuries using non-invasive methods is thus strongly recommended. Some treatments for non-melanoma carcinoma are already well defined, such as surgery, cryosurgery, curettage and electrode section, and radiotherapy; however, these conventional treatments cause inflammation and scarring. In the non-surgical treatment of non-melanoma carcinoma, the topical administration of chemotherapeutic drugs contributes for an effective treatment with reduced side effects. However, the penetration of anticancer drugs in the deeper layers of the skin is required. Lipid delivery systems (liposomes, solid lipid nanoparticles, nanostructured lipid carriers) have been developed to overcome epidermal barrier of the skin and to allow the drugs to reach tumor cells. These lipid nanoparticles contribute to control the release profile of the loaded chemotherapeutic drugs, maintaining their stability and increasing death of tumor cells. In this review, the characteristics of non-melanoma carcinoma will be discussed, describing the main existing treatments, together with the contribution of lipid delivery systems as an innovative approach to increase the effectiveness of topical therapies for non-melanoma carcinomas.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15