Semisolid formulations based on solid-in-oil-in-water systems containing proteins

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Araujo, M (Author) Other; Marques, AC (Author) FFUP; Lobo, JMS (Author) Other; Maria Helena Amaral (Author) FFUP

Journal

Title: Brazilian Journal of Pharmaceutical Sciences

Vol. 58

ISSN: 1984-8250

Publisher: Universidade de São Paulo

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00W-YTH

DOI: 10.1590/s2175-97902022e191093

Abstract (EN): In recent years, improvements have been made, through biotechnological processes, in the production and development of peptides capable of increasing collagen and elastin synthesis for anti-aging skin care. However, proteins have many limitations due to their structural, chemical and physical fragility to external aggressions, which may cause conformational changes, leading to loss of biological activity. Therefore, it is important to create delivery systems that protect these biomolecules from damage, allowing them to reach their target. This work aimed to develop a system able to carry bovine serum albumin (BSA), used as a model of a protein, and to incorporate this system in a semisolid formulation suitable for skin application. A microemulgel based on a solid-in-oil-in-water (S/O/W) microemulsion was prepared. Firstly, the association efficiency (AE) of lyophilised BSA-sucrose ester complex and the size of S/O nanodispersion were assessed; then, the characterization and stability evaluation of the final semisolid formulation through evaluation of pH, texture and theological behaviour were performed. The average value of AE was 54.74% +/- 2.17. It was possible to develop an S/O/W microemulsion, which allowed the subsequent development of an 5/0/W microemulgel that assured suitable pH, texture and rheological characteristics for skin application.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8