Mitochondria research and neurodegenerative diseases: On the track to understanding the biological world of high complexity

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Mendes, D (Author) Other; Peixoto, F (Author) Other; Oliveira, MM (Author) Other; Paula B Andrade (Author) FFUP; Videira, RA (Author) Other

Journal

Title: Mitochondrion

Vol. 65

Pages: 67-79

ISSN: 1567-7249

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-P1P

DOI: 10.1016/j.mito.2022.05.001

Abstract (EN): From the simple unicellular eukaryote to the highly complex multicellular organism like Human, mitochondrion emerges as a ubiquitous player to ensure the organism's functionality. It is popularly known as the powerhouse of the cell by its key role in ATP generation. However, our understanding of the physiological relevance of mitochondria is being challenged by data obtained in different fields. In this review, a short history of the mitochondria research field is presented, stressing the findings and questions that allowed the knowledge advances, and put mitochondrion as the main player of safeguarding organism life as well as a key to solve the puzzle of the neurodegenerative diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13