Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: A systematic review based on proteomic findings

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Branda, SR (Author) Other; Felix Carvalho (Author) FFUP; Amado, F (Author) Other; Ferreira, R (Author) Other; Costa, VM (Author) Other

Journal

Title: Metabolism: Clinical and Experimental

Vol. 134

ISSN: 0026-0495

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00W-Y99

DOI: 10.1016/j.metabol.2022.155250

Abstract (EN): Several anticancer agents have been associated with cardiac toxic effects. The currently proposed mechanisms to explain cardiotoxicity differ among anticancer agents, but in fact, the specific modulation is not completely elucidated. Thus, this systematic review aims to provide an integrative perspective of the molecular mechanisms underlying the toxicity of anticancer agents on heart muscle while using a high-throughput technology, mass spectrometry (MS)-based proteomics. A literature search using PubMed database led to the selection of 27 studies, of which 13 reported results exclusively on animal models, 13 on cardiomyocyte-derived cell lines and only one included both animal and a cardiomyocyte line. The reported anticancer agents were the proteasome

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 29