Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Goncalves, D (Author) Other; Cecilio, P (Author) Other; Faustino, A (Author) Other; Iglesias, C (Author) Other; Branca, F (Author) Other; Estrada, A (Author) Other; Helena Sousa (Author) FFUP

Journal

Title: Frontiers in Microbiology

Vol. 12

ISSN: 1664-302X

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-XV3

DOI: 10.3389/fmicb.2021.777054

Abstract (EN): The emergence of infections (and colonization) with Enterobacteriaceae-producing carbapenemases is a threatening public health problem. In the last decades, we watched an isolated case becoming a brutal outbreak, a sporadic description becoming an endemic problem. The present study aims to highlight the dissemination of IMP-22-producing Klebsiella pneumoniae in the North of Portugal, through the phenotypic and genotypic characterization of isolates collected from hospitalized patients (n=5) and out-patients of the emergency ward of the same acute care hospital (n=2), and isolates responsible for the intestinal colonization of residents in a Long-Term Care Facility (n=4). Pulsed-field gel electrophoresis (PFGE) results, associated with conjugation experiments pointed to a pattern of both vertical and horizontal dissemination. Overall, and complementing other studies that give relevance to IMP-22-producing K. pneumoniae in the clinical settings, here we show for the first time the public health threatening breach of the hospital frontier of this resistance threat, toward the community.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10