Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): A current overview of active targeting in brain diseases

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Teixeira, MI (Author) Other; Lopes, CM (Author) Other; Maria Helena Amaral (Author) FFUP; Paulo Costa (Author) FFUP

Journal

Title: Colloids and Surfaces B: Biointerfaces

Vol. 221

ISSN: 0927-7765

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00X-G73

DOI: 10.1016/j.colsurfb.2022.112999

Abstract (EN): The blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain, complicating the treatment of neurological diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), glioma, etc. To overcome this limitation and improve drug delivery to the central nervous system (CNS), the potential of nanocarriers, including lipid-based nanosystems, has been explored. Through active targeting, the surface of the nanocarriers can be modified with ligands that interact with the BBB, enhancing their uptake and penetration across the brain endothelium by different physiological mechanisms, such as receptor-or transporter-mediated transcytosis. This review seeks to provide an overview of active targeting in brain delivery, while highlighting the potential of functionalized lipid nanocarriers to treat brain diseases. Therefore, in the first sections, we discuss the importance of active targeting in CNS drug delivery, present the different ligands commonly used for functionalization, as well as summarize the state of the art of the most recent and relevant studies of surface-modified lipid nanosystems developed for neurological disorders. Lastly, challenges hindering clinical translation are discussed, and critical insights and future perspectives outlined. Although some limita-tions have been identified, it is expected that in the upcoming years these nanosystems will be an established approach.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 24