ER stress in obesity pathogenesis and management

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Ajoolabady, A (Author) Other; Liu, SM (Author) Other; Klionsky, DJ (Author) Other; Lip, GYH (Author) Other; Tuomilehto, J (Author) Other; Kavalakatt, S (Author) Other; David M Pereira (Author) FFUP; Samali, A (Author) Other; Ren, J (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: TRENDS IN PHARMACOLOGICAL SCIENCES

Vol. 43

Pages: 97-109

ISSN: 0165-6147

Publisher: Elsevier Science

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-VTV

DOI: 10.1016/j.tips.2021.11.011

Abstract (EN): Given the unprecedented global pandemic of obesity, a better understanding of the etiology of adiposity will be necessary to ensure effective management of obesity and related complications. Among the various potential factors contributing to obesity, endoplasmic reticulum (ER) stress refers to a state of excessive protein unfolding or misfolding that is commonly found in metabolic diseases including diabetes mellitus, insulin resistance (IR), and non-alcoholic fatty liver disease, although its role in obesogenesis remains controversial. ER stress is thought to drive adiposity by dampening energy expenditure, making ER stress a likely therapeutic target for the management of obesity. We summarize the role of ER stress and the ER stress response in the onset and development of obesity, and discuss the underlying mechanisms involved with a view to identifying novel therapeutic strategies for obesity prevention and management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13