Toxicometabolomics: Small Molecules to Answer Big Toxicological Questions

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Araujo, AM (Author) Other; Felix Carvalho (Author) FFUP; de Pinho, PG (Author) FFUP; Carvalho, M (Author) Other

Journal

Title: Metabolites

Vol. 11

Final page: 692

ISSN: 2218-1989

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-MDQ

DOI: 10.3390/metabo11100692

Abstract (EN): Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metabolic responses and altered biological pathways that various stressful stimuli cause in many organisms. The present review focuses on the analytical platforms and the typical workflow employed in toxicometabolomic studies, and gives an overview of recent exploratory research that applied metabolomics in various areas of toxicology.</p>

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 31