Association between intraoperative ketamine and the incidence of emergence delirium in laparoscopic surgeries: an observational study

• Type: Article in International Scientific Journal
• Date: 2024

Authors

Pereira, H (Author) FMUP; Antunes, MV (Author) Other; Teles, D (Author) Other; Pereira, LG (Author) FMUP; Abelha, F (Author) FMUP

Journal

Title: Revista Brasileira de Anestesiologia

Vol. 74

ISSN: 0034-7094

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00X-HD9

DOI: 10.1016/j.bjane.2022.10.002

Abstract (EN): Background: Emergence Delirium (ED) is an essential condition in the immediate postoperative period. Systematic review and meta -analysis of randomized controlled trials have concluded that the effect of ketamine on postoperative delirium remains unclear. The present study sought to evaluate if the intraoperative use of ketamine for postoperative analgesia is associated with postoperative ED in laparoscopic surgeries. Methods: A prospective observational study was performed in the PostAnesthetic Care Unit (PACU) to evaluate patients who had undergone laparoscopic surgery under a rigid intraoperative anesthesia protocol from July 2018 to January 2019. Patients submitted to laparoscopic surgery for cholecystectomy, oophorectomy, or salpingectomy with a score >= 1 on the Richmond Assessment Sedation Scale (RASS) or >= 2 on the Nursing Delirium Screening Scale (Nu-DESC) were considered to have ED. t -test, Chi -Square test or Fisher's exact tests were used for comparison. Results: One hundred and fifteen patients were studied after laparoscopic surgery. Seventeen patients (14.8%) developed ED, and the incidence of ED in patients who received ketamine was not different from that of other patients (18.3% vs. 10.6%, p = 0.262). Patients with ED had more postoperative pain and morphine requirement at the PACU (p = 0.005 and p = 0.025, respectively). Type of surgery (general surgery, OR = 6.4, 95% CI 1.2-35.2) and postoperative pain (OR = 3.7, 95% CI 1.2-11.4) were risk factors for ED. Conclusion: In this study, no association was found between ED and intraoperative administration of ketamine in laparoscopic surgeries. Type of surgery and postoperative pain were risk factors for ED. (c) 2022 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7