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Regulation of dopamine synthesis in the rat kidney

Title
Regulation of dopamine synthesis in the rat kidney
Type
Article in International Conference Proceedings Book
Year
1991
Authors
soares-da-silva, p
(Author)
FMUP
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Fernandes MH
(Author)
FMDUP
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Conference proceedings International
Indexing
Other information
Authenticus ID: P-007-5CC
Abstract (EN): Both animal and clinical studies clearly suggest a close link between dopamine production and renal delivery of sodium. It appears that tubular transport of sodium and DOPA could represent the rate limiting step for the renal synthesis of dopamine; the membrane transport mechanism is sensitive to the nucleotide cyclic GMP. In sodium overloaded animals AAAD activity appears to be greater than that in controls, but the tubular transport of L-DOPA might be decreased. Since the final product of an increased sodium delivery to the kidney is an increased urinary excretion of dopamine, it might be hypothesized that the outward transport of newly formed dopamine in tubular epithelial cells is also affected by high tubular sodium.
Language: English
Type (Professor's evaluation): Scientific
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