Synthesis and metabolism of dopamine in the kidney: Effects of sodium chloride, monoamine oxidase inhibitors and ¿-human atrial natriuretic peptide

• Type: Article in International Conference Proceedings Book
• Date: 1990

Authors

soares-da-silva, p (Author) FMUP; Fernandes MH (Author) FMDUP

Conference proceedings International

Title: American Journal of Hypertension

Pages: 7S-10S

Indexing

Scopus - 37 Citations

Other information

Authenticus ID: P-007-504

Abstract (EN): The synthesis of dopamine (DA) and the extent of its deamination to dihydroxyphenylacetic acid (DOPAC) in rat kidney slices loaded with L-DOPA, under in vitro conditions, has been studied. Inhibition of MAO-A increased the accumulation of newly-formed DA and reduced DOPAC formation; by contrast, the inhibition of monoamine oxidase, MAO-B, only resulted in a decrease in DOPAC formation. Raising the sodium chloride concentration in the incubation medium increases DA formation and reduces DOPAC accumulation. The addition of ¿-human atrial natriuretic peptide (¿-hANP; 3.3 and 330 nmol/L) to the incubation medium decreases DA formation; this effect was potentiated by the cGMP phosphodiesterase inhibitor M and B 22,948 and antagonized by a raise in the sodium chloride concentration to 157 mmol/L.

Language: English

Type (Professor's evaluation): Scientific