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Long-term effects of parathyroid hormone, 1,25-dihydroxyvitamin D-3, and dexamethasone on the cell growth and functional activity of human osteogenic alveolar bone cell cultures

Title
Long-term effects of parathyroid hormone, 1,25-dihydroxyvitamin D-3, and dexamethasone on the cell growth and functional activity of human osteogenic alveolar bone cell cultures
Type
Article in International Scientific Journal
Year
2000
Authors
Costa, MA
(Author)
ICBAS
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Fernandes MH
(Author)
FMDUP
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Journal
Vol. 42
Pages: 345-353
ISSN: 1043-6618
Publisher: Elsevier
Other information
Authenticus ID: P-000-YXH
Abstract (EN): The proliferation-differentiation behaviour of human alveolar bone cell cultures grown for 32 days in conditions that allowed the complete expression of the osteoblastic phenotype was significantly affected by the continuous presence of parathyroid hormone, 1,25-dihydroxyvitamin D-3, or dexamethasone. Parathyroid hormone and, in particular, dexamethasone significantly induced the differentiation of osteoblastic cells. Moreover, cultures exposed to these hormones presented an earlier appearance and higher levels of alkaline phosphatase, and an increased ability to form calcium phosphate deposits in the extracellular matrix. (C) 2000 Academic Press.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 9
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