Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and putative therapeutic targets in COVID-19 patients

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Reina Couto, M (Author) Other; Roboredo Madeira, M (Author) Other; Pereira Terra, P (Author) Other; Silva Pereira, C (Author) Other; Martins, S (Author) Other; Teixeira Santos, L (Author) Other; Pinho, Dora (Author) FMUP; Dias, A (Author) Other; Cordeiro, G (Author) Other; Dias C (Author) FMUP; Sarmento A (Author) FMUP; Tavares, M (Author) Other; guimaraes, jt (Author) FMUP; Roncon-Albuquerque R Jr (Author) FMUP; Paiva, J-A (Author) FMUP; Albino Teixeira, A (Author) FMUP; Sousa, T (Author) FMUP

Journal

Title: Inflammation Research

Vol. 72

Pages: 475-491

ISSN: 1023-3830

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 0 Citations

Other information

Authenticus ID: P-00X-QYZ

DOI: 10.1007/s00011-022-01682-z

Abstract (EN): Background Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity was also assessed. Methods Blood and spot urine were collected in severe (n = 26), critically ill (n = 17) and critically ill on VV-ECMO (n = 17) patients with COVID-19 at days 1-2 (admission), 3-4, 5-8 and weekly thereafter, and in controls (n = 23) at a single time point. U-CysLT were measured by ELISA. Routine markers, prognostic scores and outcomes were also evaluated. Results U-CysLT did not differ between groups at admission, but significantly increased along hospitalization only in critical groups, being markedly higher in VV-ECMO patients, especially in hypertensives. U-CysLT values during the first week were positively associated with ICU and total hospital length of stay in critical groups and showed acceptable area under curve (AUC) for prediction of 30-day mortality (AUC: 0.734, p = 0.001) among all patients. Conclusions U-CysLT increase during hospitalization in critical COVID-19 patients, especially in hypertensives on VV-ECMO. U-CysLT association with severe outcomes suggests their usefulness for prognostication and as therapeutic targets.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17