Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Loading of praziquantel in the crystal lattice of solid lipid nanoparticles Studies by DSC and SAXS
Publication

Publications

Loading of praziquantel in the crystal lattice of solid lipid nanoparticles Studies by DSC and SAXS

Title
Loading of praziquantel in the crystal lattice of solid lipid nanoparticles Studies by DSC and SAXS
Type
Article in International Scientific Journal
Year
2012
Authors
Ribeiro de Souza, ALR
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Andreani, T
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Nunes, FM
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Cassimiro, DL
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
de Almeida, AE
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Ribeiro, CA
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Vitorino Sarmento, VHV
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Daflon Gremiao, MPD
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Silva, AM
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Souto, EB
(Author)
Other
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page Without ORCID
Journal
Vol. 108 No. 2
Pages: 353-360
ISSN: 1388-6150
Publisher: Springer Nature
Other information
Authenticus ID: P-002-BJ8
Abstract (EN): Praziquantel (PZQ) is the drug of choice for oral treatment of schistosomiasis and other fluke infections that affect humans. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. In this article, solid lipid nanoparticles loaded with PZQ (PZQ-SLN) were prepared by a modified oil-in-water microemulsion method selecting stearic acid as lipid phase after solubility screening studies. The mean particle size (Z-Ave) and zeta potential (ZP) were 500 nm and -34.0 mV, respectively. Morphology and shape of PZQ-SLN were analysed by scanning electron microscopy revealing the presence of spherical particles with smooth surface. Differential scanning calorimetry suggested that SLN comprised a less ordered arrangement of crystals and the drug was molecularly dispersed in the lipid matrix. No supercooled melts were detected. The entrapment efficiency (EE) and loading capacity of PZQ, determined by high performance liquid chromatography, were 99.06 +/- 0.3 and 17.48 +/- 0.05, respectively. Effective incorporation of PZQ into the particles was confirmed by small angle X-ray scattering revealing the presence of a lipid lamellar structure. Stability parameters of PZQ-SLN stored at room temperature (25 degrees C) and at 4 degrees C were checked by analysing Z-Ave, ZP and the EE for a period of 60 days. Results showed a relatively long-term physical stability after storage at 4 degrees C, without drug expulsion.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 8
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Mediterranean Conference on Calorimetry and Thermal Analysis (MEDICTA) 2023 Preface (2024)
Another Publication in an International Scientific Journal
Maria D M C R Ribeiro da Silva; Silva, ALR
Volatility and chemical stability of chromium, molybdenum, and tungsten hexacarbonyls (2018)
Article in International Scientific Journal
Manuel J S Monte; Ana R R P Almeida; Rafael Notario
Vapour pressures, enthalpies and entropies of sublimation of para substituted benzoic acids (2010)
Article in International Scientific Journal
Manuel J S Monte; Luis M N B F Santos; Fonseca, JMS; Sousa, CAD
Vapour pressures, enthalpies and entropies of sublimation of para substituted benzoic acids (2010)
Article in International Scientific Journal
Manuel J S Monte; Luis M N B F Santos; Jose M S Fonseca; Carlos A D Sousa
Three N2O2 ligands derived from the condensation of 1,2-cyclohexanediaminewith salicylaldehyde, acetylacetone and benzoylacetone - A new contribution to the energetical characterization of Schiff bases (2007)
Article in International Scientific Journal
Maria Ribeiro M C R da Silva; Araujo, NRM; Silva, ALR; da Silva, LCM; Barros, NPSM; Goncalves, JM; Ribeiro A V R da Silva

See all (38)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-29 at 23:57:57 | Privacy Policy | Personal Data Protection Policy | Whistleblowing