Essential Oils as Active Ingredients of Lipid Nanocarriers for Chemotherapeutic Use

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Severino, P (Author) Other; Andreani, T (Author) Other; Chaud, MV (Author) Other; Benites, CI (Author) Other; Pinho, SC (Author) Other; Souto, EB (Author) Other

Journal

Title: Current Pharmaceutical Biotechnology

Vol. 16

Pages: 365-370

ISSN: 1389-2010

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 29 Citations

Other information

Authenticus ID: P-00G-17K

DOI: 10.2174/1389201016666150206111253

Abstract (EN): Essential oils have increased interest as promising ingredients for novel pharmaceutical dosage forms. These oils are reported to provide synergistic effects of their active ingredients, in parallel with their biodegradable properties. In addition, essential oils may also have therapeutic effects in diabetes, inflammation, cancer and to treat microbial infections. However, there are some physicochemical properties that may limit their use as active compounds in several formulations, such as high volatility, low-appealing organoleptic properties, low bioavailability and physicochemical instability, as result of exposure to light, oxygen and high temperatures. To overcome these limitations, lipid colloidal carriers (e. g. liposomes, solid lipid nanoparticles (SLN), self nanoemulsified drug delivery systems (SNEDDS)) have been pointed out as suitable carriers to improve bioavailability, low solubility, taste, flavor and long-term storage of sensitive compounds. This paper reviews the potential beneficial effects of formulating essential oils in pharmaceutical applications using colloidal carriers as delivery systems. Keywords: essential oils, colloidal system, encapsulation, biological effect, chemotherapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6