Lipid nanoparticles: Effect on bioavailability and pharmacokinetic changes

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Souto, EB (Author) Other; Muller, RH (Author) Other

Journal

Title: Handbook of Experimental Pharmacology

Vol. 10

Pages: 115-141

ISSN: 0171-2004

Publisher: Springer Nature

Indexing

Scopus - 153 Citations

Other information

Authenticus ID: P-007-TCX

DOI: 10.1007/978-3-642-00477-3_4

Abstract (EN): The main aim of pharmaceutical technology research is the design of successful formulations for effective therapy, taking into account several issues including therapeutic requirements and patient compliance. In this regard, several achievements have been reported with colloidal carriers, in particular with lipid nanoparticles, due to their unique physicochemical properties. For several years these carriers have been showing potential success for several administration routes, namely oral, dermal, parenteral, and, more recently, for pulmonary and brain targeting. The present chapter provides a review of the use of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) to modify the release profile and the pharmacokinetic parameters of active pharmaceutical ingredients (APIs) incorporated in these lipid matrices, aiming to modify the API bioavailability, either upwards or downwards depending on the therapeutic requirement. Definitions of the morphological characteristics, surface properties, and polymorphic structures will also be given, emphasizing their influence on the incorporation parameters of the API, such as yield of production, loading capacity, and encapsulation efficiency. © 2009 Springer-Verlag Berlin Heidelberg.

Language: English

Type (Professor's evaluation): Scientific