A novel approach based on lipid nanoparticles (SLN (R)) for topical delivery of alpha-lipoic acid

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Souto, EB (Author) Other; Muller, RH (Author) Other; Gohla, S (Author) Other

Journal

Title: Journal of Microencapsulation

Vol. 22

Pages: 581-592

ISSN: 0265-2048

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 44 Citations

Scopus - 60 Citations

Other information

Authenticus ID: P-00F-RVN

DOI: 10.1080/02652040500162378

Abstract (EN): This study describes the development, preparation and characterization of solid lipid nanoparticles (SLN(R)) containing the novel anti-ageing substance alpha-lipoic acid. Lipoic acid is chemically labile, i.e. the degradation products possess an unpleasant odour. Therefore, the active was encapsulated in SLN. A lipid with low melting point ( Softisan (R)601) was selected for preparation of active-loaded SLN after screening the solubility of alpha-lipoic acid in physicochemically different lipids. An entrapment efficiency of 90% (UV analysis) was obtained for all developed formulations using Miranol (R)Ultra C32 as emulsifying agent. Particle size stability was monitored during 3 months storing the samples at 20 degrees C and at 4 degrees C. Results of DSC analysis confirm that these systems are characterized by a solid-like behaviour, although with a very low crystallinity index.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12