Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN (R))

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Souto, EB (Author) Other; Anselmi, C (Author) Other; Centini, M (Author) Other; Muller, RH (Author) Other

Journal

Title: International Journal of Pharmaceutics

Vol. 295

Pages: 261-268

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 71 Citations

Other information

Authenticus ID: P-00F-R1S

DOI: 10.1016/j.ijpharm.2005.02.005

Abstract (EN): Solid lipid nanoparticles (SLN™) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, Surface electrical charge (zeta potential) and matrix crystallinity. The chemical stability of n-dodecyl-ferulate at high temperatures was also assessed by thermal gavimetry analysis. For the selection of the appropriated lipid matrix, chemically different lipids were melted with 4% (m/m) of active and lipid nanoparticles were prepared by the so-called high pressure homogenization technique. n-Dodecyl-ferulate-loaded SLN prepared with cetyl palmitate showed the lowest mean particle size and polydispersity index, as well as the highest physical stability during storage time of 21 days at 4, 20 and 40 ° C. These colloidal dispersions containing the sunscreen also exhibited the common melting behaviour of aqueous SLN dispersions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8