Self-assembling systems based on quaternized derivatives of 1,4-diazabicyclo[2.2.2]octane in nutrient broth as antimicrobial agents and carriers for hydrophobic drugs

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Pashirova, TN (Author) Other; Lukashenko, SS (Author) Other; Zakharov, SV (Author) Other; Voloshina, AD (Author) Other; Zhiltsova, EP (Author) Other; Zobov, VV (Author) Other; Souto, EB (Author) Other; Zakharova, LY (Author) Other

Journal

Title: Colloids and Surfaces B: Biointerfaces

Vol. 127

Pages: 266-273

ISSN: 0927-7765

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 32 Citations

Other information

Authenticus ID: P-00A-77R

DOI: 10.1016/j.colsurfb.2015.01.044

Abstract (EN): Aggregation properties of mono (mono-CS) and dicationic (di-CS) surfactants, namely quaternised derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO), have been evaluated in water and in nutrient broths of different pH, i.e. in Hottinger broth (pH = 7.2) and Sabouraud dextrose broth (pH = 5.6). Aggregation capacity of surfactants was shown to be responsible for the solubilization properties of a complex composed of a hydrophobic probe (Sudan I) and a selected drug (quercetin), contributing to the antimicrobial activity of this surfactant system. The effect of N-methyl-D-glucamine (NmDg) additive on the antimicrobial activity of mono-CS, and its aggregation and solubilization parameters, has also been evaluated. A substantial decrease in critical micelle concentration (CMC) of cationic surfactants in nutrient broths (up to 60 times) has been reported. Twofold dilution of monocationic surfactant by NmDg slightly changed the CMC of surfactant; however, it provided a remarkable increase in solubilization capacity (similar to by 4 times) and decrease in its toxicity. The data anticipate the potential use of DABCO quaternized derivatives as innovative non-toxic delivery systems for hydrophobic drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8