Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Severino, P (Author) Other; Fangueiro, JF (Author) Other; Ferreira, SV (Author) Other; Basso, R (Author) Other; Chaud, MV (Author) Other; Santana, MHA (Author) Other; Rosmaninho, A (Author) Other; Souto, EB (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Clinical and Translational Oncology

Vol. 15

Pages: 417-424

ISSN: 1699-048X

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-005-085

DOI: 10.1007/s12094-012-0982-0

Abstract (EN): Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8