Encapsulation of antioxidants in gastrointestinal-resistant nanoparticulate carriers

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Souto, EB (Author) Other; Severino, P (Author) Other; Basso, R (Author) Other; Santana, MHA (Author) Other

Journal

Title: Methods in molecular biology (Clifton, N.J.)

Vol. 34

Pages: 37-46

ISSN: 1064-3745

Publisher: Springer Nature

Indexing

Scopus - 35 Citations

Other information

Authenticus ID: P-008-D58

DOI: 10.1007/978-1-62703-475-3-3

Abstract (EN): Reactive oxygen species (ROS) are known to cause several human pathologies. For this reason, antioxidants have gained utmost importance because of their potential as prophylactic and therapeutic agents in many diseases. Examples of their application include their use in diabetic patients, as aging drugs, in cancer diseases, Parkinson's, Alzheimer's, autoimmune disorders, and also in inflammation. Antioxidants have limited absorption profiles, therefore low bioavailability and low concentrations at the target site. Efforts have been done towards loading antioxidant molecules in advanced nanoparticulate carriers, e.g., liposomes, polymeric nanoparticles, solid lipid nanoparticles, self-emulsifying drug delivery system. Examples of successful achievements include the encapsulation of drugs and other active ingredients, e.g., coenzyme Q10, vitamin E and vitamin A, resveratrol and polyphenols, curcumin, lycopene, silymarin, and superoxide dismutase. This review focuses on the comprehensive analysis of using nanoparticulate carriers for loading these molecules for oral administration. © Springer Science+Business Media, New York 2013.

Language: English

Type (Professor's evaluation): Scientific