Preparation of polymeric nanoparticles by polymerization of monomers - Part i [Preparação de Nanopartículas Poliméricas a partir da Polimerização de Monômeros - Parte I]

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Souto, EB (Author) Other; Severino, P (Author) Other; Santana, MHA (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Polimeros

Vol. 22

Pages: 96-100

ISSN: 0104-1428

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-008-3TN

DOI: 10.1590/s0104-14282012005000006

Abstract (EN): Polymeric nanoparticles obtained from synthetic polymers such as copolymers of methacrylic acid, acrylic esters or metacrylics, have been widely used in pharmaceuticals for encapsulation of drugs. These nanoparticles have the advantages of drug protection, controlled release, improved bioavailability and lower toxicity, resulting in greater comfort to patients and compliance to the treatment. The production of nanoparticles (nanospheres and nanocapsules) by polymerization of monomers is reviewed and discussed in this article, highlighting the technological parameters that affect the physicochemical characteristics of nanoparticles, e.g. drug solubility, phase volume, pH of polymerization, molecular weight and monomer concentration, and the nature and concentration of the surfactant.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 5