Preparation of polymeric nanoparticles from pre-formed polymers - Part II [Preparação de Nanopartículas Poliméricas a partir de Polímeros Pré-formados - Parte II]

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Souto, EB (Author) Other; Severino, P (Author) Other; Santana, MHA (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Polimeros

Vol. 22

Pages: 101-106

ISSN: 0104-1428

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-008-3TE

DOI: 10.1590/s0104-14282012005000005

Abstract (EN): Polymeric nanoparticles have been produced by pre-formed polymers using aliphatic polyesters, which have been widely used to incorporate lipophilic drugs. The production of nanoparticles (nanospheres and nanocapsules) by pre-formed polymers can be performed by emulsification-solvent evaporation, solvent replacement, salting out or by emulsification-solvent diffusion. These methods are reviewed and discussed in this article, highlighting the technological parameters that influence the physicochemical characteristics of nanoparticles, such as the solubility of drug, the volume and pH of polymerization, the molecular weight and monomer concentration and the nature and concentration of the surfactant.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 6