Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Formulating fluticasone propionate in novel PEG-containing nanostructured lipid carriers (PEG-NLC)
Publication

Publications

Formulating fluticasone propionate in novel PEG-containing nanostructured lipid carriers (PEG-NLC)

Title
Formulating fluticasone propionate in novel PEG-containing nanostructured lipid carriers (PEG-NLC)
Type
Article in International Scientific Journal
Year
2010
Authors
Doktorovova, S
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Araujo, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Garcia, ML
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Rakovsky, E
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Souto, EB
(Author)
Other
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page Without ORCID
Journal
Vol. 75
Pages: 538-542
ISSN: 0927-7765
Publisher: Elsevier
Other information
Authenticus ID: P-003-99K
Abstract (EN): The aim of this study was to develop nanostructured lipid carriers (NLC) for topical delivery of fluticasone propionate (FP) with the aim to further improve the safety profile and decrease the adverse-side effects commonly reported in topical corticotherapy. NLC are colloidal drug-carriers consisting of a blend of a solid lipid and a small amount of liquid lipid since these carriers have proved to be effective in epidermal targeting in particular of glucocorticoids. NLC consisting of glyceryl palmito-stearate, and PEG-containing medium chain triglycerides mixture, stabilised by polysorbate 80 and soybean phosphatidylcholine were prepared. A mean particle size between 380 and 408 nm and entrapment efficacy of 95% were obtained for FP-loaded NLC. The crystallinity and polymorphic phase behaviour of FP-free and FP-loaded NLC were examined by differential scanning calorimetry and wide angle X-ray diffraction. Results revealed a low-crystalline structure and confirmed the incorporation of FP into the particles. The suitability of PEG-containing liquid lipids to form the lipid matrix of NLC was also confirmed.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Nanotechnological carriers for cancer chemotherapy: The state of the art (2015)
Another Publication in an International Scientific Journal
Estanqueiro, M; Maria Helena Amaral; Conceicao, J; Sousa Lobo, JMS
3D-printed biosurfactant-chitosan antibacterial coating for the prevention of silicone-based associated infections (2023)
Article in International Scientific Journal
Narciso F; Cardoso S; Monge N; Lourenço M; Victor Martin; Duarte N; Catarina Santos ; Gomes PS; Ana Bettencourt
UV-C driven reduction of nanographene oxide opens path for new applications in phototherapy (2024)
Article in International Scientific Journal
Silva, FALS; Timochenco, L; Costa Almeida, R; Fernandes, JR; Santos, SG; Magalhães, F. D.; Artur Pinto
Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: A targeted approach for psoriasis management (2017)
Article in International Scientific Journal
Ferreira, M; Barreiros, L; Marcela A Segundo; Torres, T; Selores, M; Costa Lima, SAC; Salette Reis
The potential advantages of using a poly(HPMA) brush in urinary catheters: effects on biofilm cells and architecture (2020)
Article in International Scientific Journal
Patrícia Alves; Luciana Gomes; Mariia Vorobii; César Rodriguez-Emmenegger; Filipe Mergulhão

See all (77)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-24 at 18:56:19 | Privacy Policy | Personal Data Protection Policy | Whistleblowing