Natural Products for the Prevention and Treatment of Oral Mucositis-A Review

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Ferreira, AS (Author) Other; Macedo, C (Author) Other; Silva, AM (Author) Other; Delerue-Matos, C (Author) Other; Paulo Costa (Author) FFUP; Rodrigues, F (Author) Other

Journal

Title: International Journal Of Molecular Sciences

Vol. 23

Final page: 4385

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00W-FAH

DOI: 10.3390/ijms23084385

Abstract (EN): Cancer, a major world public health problem, is associated with chemotherapy treatments whose administration leads to secondary concerns, such as oral mucositis (OM). The OM disorder is characterized by the presence of ulcers in the oral mucosa that cause pain, bleeding, and difficulty in ingesting fluids and solids, or speaking. Bioactive compounds from natural sources have arisen as an effective approach for OM. This review aims to summarize the new potential application of different natural products in the prevention and treatment of OM in comparison to conventional ones, also providing a deep insight into the most recent clinical studies. Natural products, such as Aloe vera, Glycyrrhiza glabra, Camellia sinensis, Calendula officinalis, or honeybee crops, constitute examples of sources of bioactive compounds with pharmacological interest due to their well-reported activities (e.g., antimicrobial, antiviral, anti-inflammatory, analgesic, or wound healing). These activities are associated with the bioactive compounds present in their matrix (such as flavonoids), which are associated with in vivo biological activities and minimal or absent toxicity. Finally, encapsulation has arisen as a future opportunity to preserve the chemical stability and the drug bioa vailability of bioactive compounds and, most importantly, to improve the buccal retention period and the therapeutic effects.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 31