Dissolvable Carboxymethylcellulose Microneedles for Noninvasive and Rapid Administration of Diclofenac Sodium

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Silva, ACQ (Author) Other; Pereira, B (Author) Other; Lameirinhas, NS (Author) Other; Paulo Costa (Author) FFUP; Almeida, IF (Author) Other; Dias-Pereira, P (Author) Other; Correia-Sa, I (Author) Other; Oliveira, H (Author) Other; Silvestre, AJD (Author) Other; Vilela, C (Author) Other; Freire, CSR (Author) Other

Journal

Title: Macromolecular Bioscience

ISSN: 1616-5187

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-DZS

DOI: 10.1002/mabi.202200323

Abstract (EN): The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely of sodium carboxymethylcellulose (CMC), a water-soluble cellulose derivative with good film-forming ability, by micromolding technology for the transdermal delivery of diclofenac sodium salt (DCF). The MNs with approximate to 456 mu m in height displayed adequate morphology, thermal stability up to 200 degrees C, and the required mechanical strength for skin insertion (>0.15 N needle(-1)). Experiments in ex vivo abdominal human skin demonstrate the insertion capability of the CMC_DCF MNs up to 401 mu m in depth. The dissolution of the patches in saline buffer results in a maximum cumulative release of 98% of diclofenac after 40 min, and insertion in a skin simulant reveals that all MNs completely dissolve within 10 min. Moreover, the MN patches are noncytotoxic toward human keratinocytes. These results suggest that the MN patches produced with CMC are promising biopolymeric systems for the rapid administration of DCF in a minimally invasive manner.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11