Cutoff Values of MASK-air Patient-Reported Outcome Measures

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Sousa Pinto, B (Author) FMUP; Sa Sousa, A (Author) Other; Vieira, RJ (Author) FMUP; Amaral, R (Author) FMUP; Pereira, AM (Author) FMUP; Anto, JM (Author) Other; Klimek, L (Author) Other; Czarlewski, W (Author) Other; Mullol, J (Author) Other; Pfaar, O (Author) Other; Bedbrook, A (Author) Other; Brussino, L (Author) Other; Kvedariene, V (Author) Other; Larenas Linnemann, DE (Author) Other; Okamoto, Y (Author) Other; Ventura, MT (Author) Other; Ansotegui, IJ (Author) Other; Bosnic Anticevich, S (Author) Other; Canonica, GW (Author) Other; Cardona, V (Author) Other; Cecchi, L (Author) Other; Chivato, T (Author) Other; Cingi, C (Author) Other; Costa, E (Author) FFUP; Cruz, AA (Author) Other; Del Giacco, S (Author) Other; Devillier, P (Author) Other; Fokkens, WJ (Author) Other; Gemicioglu, B (Author) Other; Haahtela, T (Author) Other; Ivancevich, JC (Author) Other; Kuna, P (Author) Other; Kaidashev, I (Author) Other; Kraxner, H (Author) Other; Laune, D (Author) Other; Louis, R (Author) Other; Makris, M (Author) Other; Monti, R (Author) Other; Morais Almeida, M (Author) Other; Mosges, R (Author) Other; Niedoszytko, M (Author) Other; Papadopoulos, NG (Author) Other; Patella, V (Author) Other; Pham Thi, N (Author) Other; Regateiro, FS (Author) Other; Reitsma, S (Author) Other; Rouadi, PW (Author) Other; Samolinski, B (Author) Other; Sheikh, A (Author) Other; Sova, M (Author) Other; Taborda Barata, L (Author) Other; Toppila Salmi, S (Author) Other; Sastre, J (Author) Other; Tsiligianni, I (Author) Other; Valiulis, A (Author) Other; Yorgancioglu, A (Author) Other; Zidarn, M (Author) Other; Zuberbier, T (Author) Other; Fonseca, J (Author) FMUP; Bousquet, J (Author) Other

Journal

Title: Journal of Allergy and Clinical Immunology: In Practice

Vol. 11

Pages: 1281-+

ISSN: 2213-2198

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00X-P5V

DOI: 10.1016/j.jaip.2022.12.005

Abstract (EN): BACKGROUND: In clinical and epidemiological studies, cutoffs of patient-reported outcome measures can be used to classify patients into groups of statistical and clinical relevance. However, visual analog scale (VAS) cutoffs in MASK-air have not been tested. OBJECTIVE: To calculate cutoffs for VAS global, nasal, ocular, and asthma symptoms.METHODS: In a cross-sectional study design of all MASK-air participants, we compared (1) approaches based on the percen-tiles (tertiles or quartiles) of VAS distributions and (2) data -driven approaches based on clusters of data from 2 comparators (VAS work and VAS sleep). We then performed sensitivityanalyses for individual countries and for VAS levels corre-sponding to full allergy control. Finally, we tested the different approaches using MASK-air real-world cross-sectional and lon-gitudinal data to assess the most relevant cutoffs.RESULTS: We assessed 395,223 days from 23,201 MASK-air users with self-reported allergic rhinitis. The percentile-oriented approach resulted in lower cutoff values than the data-driven approach. We obtained consistent results in the data-driven approach. Following the latter, the proposed cutoff differenti-ating controlled and partly-controlled patients was similar to the cutoff value that had been arbitrarily used (20/100). However, a lower cutoff was obtained to differentiate between partly-controlled and uncontrolled patients (35 vs the arbitrarily-used value of 50/100).CONCLUSIONS: Using a data-driven approach, we were able to define cutoff values for MASK-air VASs on allergy and asthma symptoms. This may allow for a better classification of patients with rhinitis and asthma according to different levels of control, supporting improved disease management. (c) 2022 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:1281-9)

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14