Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Collatuzzo, G (Author) Other; Alicandro, G (Author) Other; Bertuccio, P (Author) Other; Pelucchi, C (Author) Other; Bonzi, R (Author) Other; Palli, D (Author) Other; Ferraroni, M (Author) Other; Ye, WM (Author) Other; Plymoth, A (Author) Other; Zaridze, D (Author) Other; Maximovich, D (Author) Other; Aragones, N (Author) Other; Castano Vinyals, G (Author) Other; Vioque, J (Author) Other; de la Hera, MG (Author) Other; Zhang, ZF (Author) Other; Hu, JF (Author) Other; Lopez Carrillo, L (Author) Other; Lopez Cervantes, M (Author) Other; Dalmartello, M (Author) Other; Mu, LN (Author) Other; Ward, MH (Author) Other; Rabkin, C (Author) Other; Yu, GP (Author) Other; Camargo, MC (Author) Other; Curado, MP (Author) Other; Lunet N (Author) FMUP; Negri, E (Author) Other; La Vecchia, C (Author) Other; Boffetta, P (Author) Other

Journal

Title: Journal of Epidemiology and Community Health

Vol. 76

Pages: 861-866

ISSN: 0143-005X

Publisher: BMJ PUBLISHING GROUP

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00W-YK4

DOI: 10.1136/jech-2022-219074

Abstract (EN): Background Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC. Methods We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC. Results PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC. Conclusions Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6