Application of a Fiber Optic Refractometric Sensor to Measure the Concentration of Paracetamol in Crystallization Experiments

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Soares, L (Author) Other; Cruz, P (Author) Other; Novais, S (Author) Other; A. Ferreira (Author) FEUP; Frazao, O (Author) FEUP; Susana Silva (Author) FCUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: IEEE Instrumentation and Measurement Magazine

Vol. 24

Pages: 36-40

ISSN: 10946969

Publisher: Institute of Electrical and Electronics Engineers (IEEE)

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00V-8AA

DOI: 10.1109/mim.2021.9491002

Abstract (EN): A refractometric sensor was applied to measure in real-time the concentration of Active Pharmaceutical Ingredients (APIs) in crystallization experiments. Paracetamol was used as a model system due to the extensive literature available for this API. The refractometric sensor was fabricated by a simple and inexpensive method that consisted in splicing a short section of a multimode fiber to a single mode fiber. The compact geometry of this sensor, with an external diameter of just $125\ \mu\mathrm{m}$, allowed it to measure the concentration of paracetamol, both in a stirred tank crystallizer operating in batch and in an oscillatory flow crystallizer operating continuously. The proposed technique shows the potential to monitor the concentration of APIs in crystallizers of different sizes and geometries as an alternative to more expensive and complex analysis equipment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5