Photoluminescent and visual determination of ibandronic acid using a carbon dots/AgInS2 quantum dots ratiometric sensing platform

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Castro, RC (Author) Other; Pascoa, RNMJ (Author) Other; Lucia L M F S Saraiva (Author) FFUP; Joao L M Santos (Author) FFUP; Ribeiro, DSM (Author) Other

Journal

Title: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

Vol. 267

ISSN: 1386-1425

Publisher: Elsevier

Indexing

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Other information

Authenticus ID: P-00V-PPS

DOI: 10.1016/j.saa.2021.120592

Abstract (EN): A sensing platform combining carbon dots (CDs, with blue emission) and thiomalic acid (TMA)-capped AgInS2 quantum dots (QDs, with orange emission) was developed aiming the photoluminescence (PL) ratiometric determination of ibandronic acid (IBAN), a bisphosphonate pharmaceutical. The ternary AgInS2 QDs were used for IBAN probing, undergoing a concentration-related PL quenching in its presence, whilst the PL of CDs remained practically unaffected due to its chemical inertness towards the antiresorptive drug, provided an intrinsic self-reference fluorophore. In addition, a visual sensing approach was also proposed, employing for the first time ternary QDs. This relied on RGB images acquired by means of a digital camera and seek the development of a rapid IBAN screening test. The developed sensing platforms were employed for IBAN determination in samples with pharmaceutical interest providing good results, in accordance to the reported IBAN levels, and obtaining recovery values between 98 and 103%.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12